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TriStar Centennial Medical Center

Desloratadine for Allergies

Image for clarinex Desloratadine is approved for the treatment of perennial allergic rhinitis and long term hives in people aged 6 months and older. For those who suffer from seasonal allergic rhinitis (SAR), the medication can be used at age 2 years and up.

Defining Allergic Rhinitis

SAR (or hay fever) occurs during specific times of the year when allergens (things you are allergic to) are in the air. Seasonal allergies are usually at their peak during spring or fall. Perennial allergic rhinitis is related to allergies present year-round, such as cat, dog, or dustmite.

When you breathe in an allergen, cells in your nasal passages release a chemical called histamine. Histamine causes your nose to feel itchy and increases swelling and mucus production in the nasal passages.

The following are symptoms of allergic rhinitis:

  • Sneezing
  • Itching in the nose, eyes, throat, and ears
  • Red, watery eyes
  • Runny nose, nasal congestion
  • Sinus pressure
  • Postnasal drip and cough
  • Headache
  • Dark circles under your eyes

About Desloratadine

Desloratadine is taken once per day. It is a non-sedating antihistamine, which means it blocks the action of the released histamine with less risk of making you feel drowsy.

Some of the most common side effects experienced by those taking desloratadine are:

  • Sore throat
  • Dry mouth
  • Sleepiness
  • Fatigue
  • Sore muscles

General Precautions

Desloratadine is not for everyone. Safety in children younger than 6 months has not been established. In addition, there have been no adequate and well-controlled studies in pregnant women, and desloratadine passes into breast milk. So, if you are pregnant or nursing, talk with your doctor about possible alternative options for treating SAR.

If you cannot take desloratadine, you do have options for relief.


Other antihistamines or teatments may help you manage your allergies. Options include:

  • Other oral antihistamines (eg, fexofenadine, cetirizine)
  • Intranasal steroid sprays (eg, fluticasone, triamcinolone)
  • Intranasal antihistamines sprays (eg, azelastine, olopatadine)
  • Immunotherapy, such as sublingual liquid or pills or allergy shots

Talk to your doctor about the alternatives and what may work best for you.

  • American Academy of Allergy, Asthma and Immunology

  • Food and Drug Administration

  • Canadian Society of Allergy and Clinical Immunology

  • Health Canada

  • Allergic rhinitis. EBSCO DynaMed website. Available at: Updated July 14, 2014. Accessed December 11, 2014.

  • Desloratadine. EBSCO DynaMed website. Available at: Updated January 18, 2013. Accessed December 14, 2014.

  • Desloratadine. United States National Library of Medicine from National Institutes of Health website. Available at: Updated October 1, 2010. Accessed December 14, 2014.

The health information in this Health Library is provided by a third party. TriStar Health does not in any way create the content of this information. It is provided solely for informational purposes. It does not constitute medical advice and is not intended to be a substitute for proper medical care provided by a physician. Always consult with your doctor for appropriate examinations, treatment, testing, and care recommendations. Do not rely on information on this site as a tool for self-diagnosis. If you have a medical emergency, call 911.