Skip to main content
Average ER Wait Time
Checking ER Wait Time
The feed could not be reached
Retry?
TriStar Centennial Medical Center
--
mins

Penicillamine

Trade Names :

  • Cuprimine
  • Depen

The drug penicillamine is primarily used to treat Wilson's disease (an inherited disorder affecting copper metabolism, causing cirrhosis and brain and eye problems) and rheumatoid arthritis.

 

Copper

When used to treat Wilson's disease, penicillamine works by removing copper from the body. Taking copper supplements while you are using penicillamine for this condition is not a good idea.

Vitamin B6

Penicillamine might increase the need for vitamin B 6 . 1 Taking 25 to 50 mg of supplemental B 6 daily is often recommended. 2

Zinc

Long-term use of penicillamine can cause zinc deficiency. 3 However, zinc can impair penicillamine absorption, so do not take zinc supplements during the 2 hours before or after your penicillamine dose. 4

Iron

Penicillamine attaches to the mineral iron, which impairs the absorption of both substances. 5,6 The solution: If you need iron supplements, do not take them during the 2 hours before or after your penicillamine dose.

Revision Information

  • 1

    Rumsby PC and Shepherd DM. The effect of penicillamine on vitamin B 6 function in man. Biochem Pharmacol 30: 3051–3053, 1981.

  • 2

    Pronsky Z (ed.). Powers and Moore's food medication interactions, 10th ed. Pottstown, PA: Food-Medication Interactions, 1997: 182.

  • 3

    Multicentre Trial Group. Controlled trial of D(-) penicillamine in severe rheumatoid arthritis. Lancet 1: 275–280, 1973.

  • 4

    Pronsky Z (ed.). Powers and Moore's food medication interactions, 10th ed. Pottstown, PA: Food-Medication Interactions, 1997: 182.

  • 5

    Campbell NR and Hasinoff BB. Iron supplements: a common cause of drug interactions. Br J Clin Pharmacol 31(3): 251–255, 1991.

  • 6

    Pronsky Z (ed.). Powers and Moore's food medication interactions, 10th ed. Pottstown, PA: Food-Medication Interactions, 1997: 182.

The health information in this Health Library is provided by a third party. TriStar Health does not in any way create the content of this information. It is provided solely for informational purposes. It does not constitute medical advice and is not intended to be a substitute for proper medical care provided by a physician. Always consult with your doctor for appropriate examinations, treatment, testing, and care recommendations. Do not rely on information on this site as a tool for self-diagnosis. If you have a medical emergency, call 911.